简体中文

AC-27-细胞间桥型

同义词 干体（stem body）、中间体（midbody） Stem body, midbody
描述
染色定位于细胞分裂期间连接两个子细胞的胞间桥，待细胞完全分离后该染色信号消失。
Staining of the intercellular bridge that connects daughter cells during cell division but dissipates when cells are completely separated
抗原相关性
CENP-E、CENP-F、TD60、MSA36、KIF-14、MKLP-1、MPP1/KIF20B及INCENP。部分含CENP-F自身抗体的患者血清亦可呈现抗干体/中间体染色，但目前尚无证据表明该染色信号即由CENP-F本身所介导。
CENP-E, CENP-F, TD60, MSA36, KIF-14, MKLP-1, MPP1/KIF20B, and INCENP. Some human sera with CENP-F autoantibodies also demonstrate anti-stem body/midbody staining but there is no evidence that this staining is CENP-F itself

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ▶AC-27核型对任何疾病的阳性预测值均较低[1]。
    ▶在常规诊断中罕见检出[2]。
    ▶目前尚无针对已知靶抗原自身抗体的商业化特异性免疫检测试剂盒[1,3]。

    ▶The AC-27 pattern has low positive predictive value for any disease [1].
    ▶Found infrequently in a routine diagnostic setting [2].
    ▶Specific immunoassays for autoantibodies to recognized antigens are currently not commercially available [1, 3].
  • 二级信息
    Second level information

  • ▶该核型已在系统性硬化症（SSc）、雷诺现象及恶性肿瘤患者中有所描述[2,4,5]。
    ▶抗CENP-E、CENP-F、TD60、MSA36、KIF-14及MKLP-1自身抗体已在SSc（局限型与弥漫型）、系统性红斑狼疮及恶性肿瘤患者中报道[1,6]。
    ▶抗INCENP自身抗体曾在1例Graham-Little-Piccardi-Lasseur综合征患者中被描述[3]。
    ▶抗MPP1/KIF20B（M期磷蛋白1）自身抗体已在特发性共济失调、其他神经系统综合征及阵发性睡眠性血红蛋白尿症患者中被报道[7,8]。
    注： 多数报道所描述的抗体，是直接与特定抗原结合的自身抗体（即基于抗原的特异性免疫检测），并未实际证实其与AC-27核型本身的相关性。

    ▶Described in patients with systemic sclerosis (SSc), Raynaud’s phenomenon, and malignancy [2, 4, 5].
    ▶Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), systemic lupus erythematosus, and malignancies [1, 6].
    ▶Autoantibodies to INCENP have been described in a single patient with Graham-Little-Piccardi-Lasseur Syndrome [3].
    ▶Autoantibodies to MPP1 /KIF20B (M-phase phosphoprotein 1) have been described in patients with idiopathic ataxia, other neurological syndromes and paroxysmal nocturnal hemoglobinuria [7, 8].
    Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunoassays) and do not actually show correlations with the AC-27 pattern as such.
  • 参考文献

  • 1.Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep. 1998;25:143-55.
    2.Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev. 2013;12:998-1003.
    3.Rodriguez-Bayona B, Ruchaud S, Rodriguez C, Linares M, Astola A, Ortiz M, Earnshaw WC, Valdivia MM. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis. 2007;4:1.
    4.Fritzler MJ, Ayer LM, Gohill J, O'Connor C, Laxer RM, Humbel RL. An antigen in metaphase chromatin and the midbody of mammalian cells binds to scleroderma sera. J Rheumatol. 1987;14:291-4.
    5.Tausche AK, Conrad K, Seidel W, Roch B. Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis? Ann Rheum Dis. 2005;64:1237-8.
    6.Fritzler MJ, Rattner JB, Luft LM, Edworthy SM, Casiano CA, Peebles C, Mahler M. Historical perspectives on the discovery and elucidation of autoantibodies to centromere proteins (CENP) and the emerging importance of antibodies to CENP-F. Autoimmun Rev. 2011;10:194-200.
    7.Fritzler MJ, Kerfoot SM, Feasby TE, Zochodne DW, Westendorf JM, Dalmau JO, Chan EKL. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). J Investig Med. 2000;48:28-39.
    8.Alahmad A, Preuss KD, Schenk J, Fureder W, Schrezenmeier H, Muller-Lantzsch N, Schubert J, Pfreundschuh M. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2010;151:273-80.

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