简体中文

AC-28-染色体型

同义词 染色体表层蛋白，分裂细胞抗原，有丝分裂染色体自身抗原（MCA） Chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
描述
细胞分裂前期和中期染色体可见点状染色，间期细胞无染色。
Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells
抗原相关性
修饰的组蛋白H3，MCA1，MCA5和DCA
Modified histone H3, MCA1, MCA5, and DCA

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ▶AC-28核型对任何疾病的阳性预测值均较低。
    ▶在常规血清学诊断中非常少见[1]。
    ▶所识别的抗原包括 DCA、MCA1和 MCA5；这些自身抗体的特异性免疫检测试剂目前尚未商品化[1-3]。



    ▶The AC-28 pattern has low positive predictive value for any disease.
    ▶Found infrequently in a routine diagnostic setting [1].
    ▶Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available [1-3].
  • 二级信息
    Second level information
  • ▶抗DCA自身抗体曾在系统性红斑狼疮患者中被检出[2]。
    ▶抗MCA1自身抗体曾在癌症患者中被检出[3]。
    ▶抗MCA5自身抗体曾在盘状红斑性狼疮、慢性淋巴细胞性白血病、 干燥综合征和风湿性多肌痛症患者中被检出[1]。
    ▶Autoantibodies to DCA have been described in patients with systemic lupus erythematosus [2].
    ▶Autoantibodies to MCA1 have been described in patients with cancer [3].
    ▶Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, Sjögren disease, and polymyalgia rheumatica [1].
  • 参考文献
  • 1.Gitlits VM, Macaulay SL, Toh BH, Sentry JW. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med. 2000;48:172-82.
    2.Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol. 1993;13:329-38.
    3.Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies. 2006;15:71-80.

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