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AC-23-胞浆棒环状型

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描述

间期细胞胞质内有明显的杆状和环状结构。也有报道指细胞核中出现较小的杆或环状染色。

 Distinct rod and ring structures in the cytoplasm of interphase cells. Some smaller rods and rings also reported in the nucleus.
抗原相关性 IMPDH2 IMPDH2

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations


  • ►AC-23核型在接受聚乙二醇干扰素-α联合利巴韦林治疗的HCV患者中最常见，但自身抗体揭示AC-23核型在治疗前未检出。随着聚乙二醇干扰素-α联合利巴韦林在HCV治疗中使用的减少，AC-23核型的频率和临床关联可能会改变 (98–101)

    ►检测针对棒环状型特异抗原 (例如IMPDH2) 的自身抗体的特异性免疫检测试剂目前尚未商品化

    注：AC-23核型的存在取决于HEp-2细胞基质。



    ► Most commonly found in HCV patients who have been treated with pegylated interferon-α/ribavirin combination therapy, but autoantibodies revealing the AC-23 patterns were undetected prior to treatment; as the use of interferon-α/ribavirin in HCV treatment is decreasing, the frequency and clinical associations of the AC-23 pattern may change (98–101)

    ► Specific immunoassays to detect autoantibodies directed to specific Rods and Rings antigens, for instance IMPDH2, are not commercially available

    Note: Presence of the AC-23 pattern depends on the HEp-2 cell substrate.

  • 一级信息参考文献
    First level information references


  • 98. Covini G, Carcamo WC, Bredi E, et al. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther 2012;17:805–11.

    99. Calise SJ, Keppeke GD, Andrade LE, et al. Anti-rods/rings: a human model of drug-induced autoantibody generation. Front Immunol 2015;6.

    100. Novembrino C, Aghemo A, Ferraris Fusarini C, et al. Interferon-ribavirin therapy induces serum antibodies determining ’rods and rings’ pattern in hepatitis C patients. J Viral Hepat 2014;21:944–9.

    101. Keppeke GD, Calise SJ, Chan EK, et al. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy. World J Gastroenterol 2016;22:1966–74.



    98. Covini G, Carcamo WC, Bredi E, et al. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther 2012;17:805–11.

    99. Calise SJ, Keppeke GD, Andrade LE, et al. Anti-rods/rings: a human model of drug-induced autoantibody generation. Front Immunol 2015;6.

    100. Novembrino C, Aghemo A, Ferraris Fusarini C, et al. Interferon-ribavirin therapy induces serum antibodies determining ’rods and rings’ pattern in hepatitis C patients. J Viral Hepat 2014;21:944–9.

    101. Keppeke GD, Calise SJ, Chan EK, et al. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy. World J Gastroenterol 2016;22:1966–74.

  • 二级信息
    Second level information

  • ►据报道，AC-23型呈阳性的HCV患者的疾病对治疗更具耐药性，但在其他人群中尚未得到证实（40）

    ►AC-23核型也很少在未感染HCV的个体中检出，包括系统性红斑狼疮患者和正在接受麦考酚酸、硫唑嘌呤、甲氨蝶呤或阿昔洛韦治疗的患者，以及自身抗体滴度较低的一般人群 (39-42)


    ► HCV patients positive for the AC-23 pattern have been reported to have disease that is more resistant to therapy, but this is not confirmed in other cohorts (40)

    ► The AC-23 pattern has also been reported rarely in individuals without HCV infection, including SLE patients and patients under treatment with mycophenolic acid, azathioprine, methotrexate or acyclovir, as well as with lower titers in the general population (39-42)

  • 二级信息参考文献
    Second level information references

  • 39. Satoh M, Chan EKL, Ho LA, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012;64:2319-27.

    40. Climent J, Morandeira F, Castellote J, et al. Clinical correlates of the "rods and rings" antinuclear antibody pattern. Autoimmunity 2016;49:102-8.

    41. Covini G, Carcamo WC, Bredi E, et al. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther 2012;17:805-11.

    42. Keppeke GD, Prado MS, Nunes E, et al. Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings antibodies. Clin Immunol 2016;173:149-56.


    39. Satoh M, Chan EKL, Ho LA, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012;64:2319-27.

    40. Climent J, Morandeira F, Castellote J, et al. Clinical correlates of the "rods and rings" antinuclear antibody pattern. Autoimmunity 2016;49:102-8.

    41. Covini G, Carcamo WC, Bredi E, et al. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther 2012;17:805-11.

    42. Keppeke GD, Prado MS, Nunes E, et al. Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings antibodies. Clin Immunol 2016;173:149-56.

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