简体中文

AC-23-胞浆棒环状型

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描述
间期细胞胞质内可见独特的杆状及环状结构。亦有报道称，部分较小的杆状及环状结构可出现在细胞核内[1]。由于这些结构被认为是主要由次黄嘌呤核苷-5'-单磷酸脱氢酶2（IMPDH2）组成的纤维样结构，当前细胞生物学文献开始采用“IMPDH纤维丝”或“胞丝体”（cytoophidia）这一术语对其进行描述[1]
Distinct rod and ring structures in the cytoplasm of interphase cells. Some smaller rods and rings also reported in the nucleus [1]. Because these structures are considered filaments primarily composed of inosine-5-monophosphate dehydrogenase 2 (IMPDH2), the current literature in cell biology is beginning to use the term IMPDH filaments or cytoophidia to describe them [1]
抗原相关性
次黄嘌呤核苷-5'-单磷酸脱氢酶2（IMPDH2）
IMPDH2

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations
  • ▶该核型最常见于接受聚乙二醇干扰素-α/利巴韦林联合治疗的丙型肝炎病毒（HCV）患者，尤其多见于治疗无效者。呈现AC-23核型的自身抗体在治疗前无法检出[1-5]。
    ▶目前尚无针对杆状及环状结构特异性抗原（如IMPDH2）的商业化自身抗体检测试剂盒。
    注： AC-23核型的检出与否取决于HEp-2细胞底物的生产厂商。
    ▶Most commonly found in hepatitis C virus (HCV) patients who had been treated with pegylated interferon-α/ribavirin combination therapy, especially in patients refractory to treatment. Autoantibodies revealing the AC-23 patterns were undetected prior to treatment [1-5].
    ▶Specific immunoassays to detect autoantibodies directed to specific Rods and Rings antigens, for instance IMPDH2, are not commercially available.
    Note: Presence of the AC-23 pattern depends on the manufacturer of the HEp-2 cell substrate.
  • 二级信息
    Second level information
  • ▶随着干扰素-α/利巴韦林在丙型肝炎治疗中的应用逐渐减少，AC-23核型的检出频率及其临床关联性可能随之发生变化。
    ▶As the use of interferon-α/ribavirin in HCV treatment is decreasing, the frequency and clinical associations of the AC-23 pattern may change.
  • 参考文献
  • 1.Calise SJ, Chan EKL. Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery. Autoimmun Rev. 2020;19:102643.
    2.Covini G, Carcamo WC, Bredi E, von Muhlen CA, Colombo M, Chan EKL. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther. 2012;17:805-11.
    3.Calise SJ, Keppeke GD, Andrade LE, Chan EKL. Anti-rods/rings: a human model of drug-induced autoantibody generation. Front Immunol. 2015;6:41.
    4.Novembrino C, Aghemo A, Ferraris Fusarini C, Maiavacca R, Matinato C, Lunghi G, Torresani E, Ronchi M, et al. Interferon-ribavirin therapy induces serum antibodies determining 'rods and rings' pattern in hepatitis C patients. J Viral Hepat. 2014;21:944-9.
    5.Keppeke GD, Calise SJ, Chan EKL, Andrade LE. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-alpha/ribavirin therapy. World J Gastroenterol. 2016;22:1966-74.

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