简体中文

AC-31-多散点型

同义词 AC-4a, 核细颗粒型 chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
描述 在核质中可见无数细小而离散的散点颗粒，呈现出该模式特征性的“多散点”核型。核仁不被染色。在有丝分裂细胞（中期、后期和末期），染色体染色阴性，而其周围的胞浆则呈现明显的染色 Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.
抗原相关性 AC-31核型与抗TROVE2/Ro60抗体（曾称为SS-A/Ro60（1）高度相关（2-4）。相比之下，单纯的细颗粒型（AC-4）与抗TROVE2/Ro60抗体的的相关性要低得多。当抗TROVE2/Ro60阳性样本中存在其他抗核抗体时，往往会掩盖AC-31模型的典型特征，因此这类阳性样本可能不会呈现预期的AC-31模型（4）。 modified histone H3, MCA-1

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ▶由于AC-31核型与抗TROVE2/Ro60抗体具有强烈相关性，该核型常见于系统性红斑狼疮(SLE)和干燥综合征(SjD)患者。与AC-4核细颗粒型相比(该核型是无症状人群及非自身免疫性疾病患者中最常见的荧光核型之一)，但AC-31核型在健康个体中并不常见。

    ► The AC-28 pattern has low positive predictive value for any disease

    ► Found very infrequently in a routine serology diagnostic setting (120)

    ► Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)

  • 一级信息参考文献
    First level information references

  • 1.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al. Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation. 2025.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al. Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop. Autoimmun Rev. 2024;23:103608.

    3.Dellavance A, Alvarenga RR, Rodrigues SH, Barbosa SH, Camilo AC, Shiguedomi HS, Rodrigues SS, Silva CG, et al. Autoantibodies to 60kDa SS-A/Ro yield a specific nuclear myriad discrete fine speckled immunofluorescence pattern. J Immunol Methods. 2013;390:35-40.

    4.Rober N, Dellavance A, Ingenito F, Reimer ML, Carballo OG, Conrad K, Chan EKL, Andrade LEC. Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers. Front Immunol. 2021;12:730102.

    120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.

    121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.

    122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.

  • 二级信息
    Second level information
  • 无

    ► Autoantibodies to DCA have been described in patients with SLE (18)

    ► Autoantibodies to MCA1 have been described in patients with carcinoma (19)

    ► Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)

  • 二级信息参考文献
    Second level information references
  • 无

    18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.

    19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.

    20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.


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