简体中文

AC-13-PCNA型样

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描述
核多形性型荧光染色的特征为斑点大小及亮度不一。间期细胞中，部分细胞呈阴性（G1期），部分细胞呈强阳性染色（S期），另有部分细胞显示稀少且散在分布的斑点，偶尔伴核仁染色（S晚期至G2早期）。有丝分裂期细胞不着色。
Pleomorphic speckled nucleoplasmic staining is characterized as variability in size and brightness of the speckles. In interphase cells, some cells are negative (G1 phase), some are intensely stained (S-phase) and some demonstrate rare and scattered speckles with occasional nucleolar staining (late S and early G2 phases). M-phase cells are not stained.
抗原相关性 PCNA（增殖细胞核抗原，35 kDa/DNA聚合酶δ辅助蛋白延伸因子） PCNA (proliferating cell nuclear antigen, 35 kDa/elongation factor of DNA polymerase delta auxiliary protein).

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ▶AC-13核型曾被认为对系统性红斑狼疮（SLE）具有高度特异性，但这一特异性现已受到质疑[1,2]。
    ▶若临床疑似SLE，建议进行PCNA抗体后续检测。
    ▶近期基于抗原特异性免疫分析的研究显示，该核型与系统性硬化症、特发性炎症性肌病、类风湿关节炎、丙型肝炎病毒感染及其他疾病状态存在临床关联[2-4]。


    ▶The AC-13 pattern was considered highly specific for systemic lupus erythematosus (SLE), but this specificity has been challenged [1, 2]
    ▶If SLE is clinically suspected, it is recommended to perform a follow-up test for PCNA antibodies
    ▶Recent studies with antigen-specific immunoassays show clinical associations with systemic sclerosis, idiopathic inflammatory myopathies, rheumatoid arthritis, hepatitis C viral infection, and other conditions [2-4]
  • 二级信息
    Second level information
  • 其他不同于AC-13核型的核多形性染色模式，应报告为未分类核型（AC-XX），并附以相应的描述性说明。
    ▶Other nuclear pleomorphic patterns that are distinct from AC-13 should be reported as unclassified patterns (AC-XX) with an appropriate description
  • 参考文献
  • 1.Miyachi K, Fritzler MJ, Tan EM. Autoantibody to a nuclear antigen in proliferating cells. J Immunol. 1978;121:2228-34
    2.Vermeersch P, De Beeck KO, Lauwerys BR, Van den Bergh K, Develter M, Marien G, Houssiau FA, Bossuyt X. Antinuclear antibodies directed against proliferating cell nuclear antigen are not specifically associated with systemic lupus erythematosus. Ann Rheum Dis. 2009;68:1791-3
    3.Mahler M, Miyachi K, Peebles C, Fritzler MJ. The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA). Autoimmun Rev. 2012;11:771-5
    4.Hsu TC, Tsay GJ, Chen TY, Liu YC, Tzang BS. Anti-PCNA autoantibodies preferentially recognize C-terminal of PCNA in patients with chronic hepatitis B virus infection. Clin Exp Immunol. 2006;144:110-6

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