简体中文

AC-15-胞浆线性/肌动蛋白型

同义词 肌动蛋白类 actin-like
描述 该（荧光）核型的特点是在细胞的长轴方向上分布有贯穿的纤维状结构。这些细胞骨架纤维有时可见点缀着间断的小颗粒状沉积物。
This pattern is characterized by fibers spanning the long axis of the cells. These cytoskeletal fibers are sometimes decorated with small, discontinuous granular deposits.
抗原相关性 肌动蛋白，非肌细胞肌球蛋白 actin, non-muscle myosin

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations


  • 抗肌动蛋白自身抗体：

    ▶ 可见于1型自身免疫性肝炎（AIH type 1）、慢性丙型肝炎病毒（HCV）感染和乳糜泻（CD）患者；在系统性自身免疫性风湿病中罕见。
    ▶ 若临床怀疑为1型自身免疫性肝炎，建议进一步通过平滑肌抗体（IgG同型） 来确认反应性，该抗体通常采用啮齿类动物组织（肝、胃、肾）为底物的间接免疫荧光法（IFA）检测；抗平滑肌抗体已被纳入1型自身免疫性肝炎的国际诊断标准[1]。F-肌动蛋白是1型自身免疫性肝炎中抗平滑肌抗体的主要靶抗原。
    ▶ 抗F-肌动蛋白自身抗体的临床意义较抗G-肌动蛋白抗体更为重要[2-4]。
    ▶ 若临床怀疑为乳糜泻，IgA型抗肌动蛋白抗体阳性与更具侵袭性的疾病形式相关，该类型常伴有严重的肠道黏膜损伤[5-7]。
    备注： 尽管市面上已有抗F-肌动蛋白的免疫学检测试剂盒可供使用，但应充分考虑这些检测方法在灵敏度方面存在的技术性问题。




    Autoantibodies to actin:

    ▶Found in patients with autoimmune hepatitis (AIH) type 1, chronic hepatitis C virus (HCV) infection, and celiac disease (CD); rare in systemic autoimmune rheumatic diseases.
    ▶If AIH type 1 is clinically suspected, it is recommended to confirm reactivity with smooth muscle antibodies (IgG isotype), typically detected by IFA on rodent tissue (liver, stomach, kidney); anti-smooth muscle antibodies are included in the international criteria for AIH type 1 [1]. F-actin is the main target antigen of anti-smooth muscle antibodies in AIH type 1.
    ▶Autoantibodies to F-actin are more clinically important than antibodies to G-actin [2-4].
    ▶If CD is clinically suspected, positive IgA anti-actin is correlated with an aggressive form involving severe intestinal mucosa damage [5-7].
    Notes: Although anti-F-actin immunoassays are commercially available, technical issues relating to the sensitivity of these immunoassays should be taken into consideration.
  • 二级信息
    Second level information


  • 抗肌动蛋白自身抗体：

    ▶ 在乳糜泻[8, 9]和原发性硬化性胆管炎[10]中，已报道存在高比例的IgA型和/或IgG型抗肌动蛋白抗体。
    抗非肌型肌球蛋白自身抗体：
    ▶ 在3例HCV阳性慢性肝炎/肝硬化患者中，已描述存在抗非肌型肌球蛋白自身抗体[11]。
    ▶ 在慢性淋巴细胞白血病中，已有针对非肌型肌球蛋白的单克隆抗体的报道[12]。
    备注： 目前市面上尚无针对非肌型肌球蛋白的特异性免疫学检测试剂盒可供使用




    Autoantibodies to actin:

    ▶High prevalence of IgA and/or IgG type anti-actin antibodies have been reported in celiac disease [8, 9] and primary sclerosing cholangitis [10].
    Autoantibodies to non-muscle myosin:
    ▶Autoantibodies to non-muscle myosin have been described in 3 patients with HCV-positive chronic hepatitis/liver cirrhosis [11].
    ▶Monoclonal antibodies to non-muscle myosin have been reported in chronic lymphocytic leukemia [12].
    Note: Specific immunoassays for non-muscle myosin are currently not commercially available.
  • 参考文献

  • 1.Liberal R, Grant CR, Longhi MS, Mieli-Vergani G, Vergani D. Diagnostic criteria of autoimmune hepatitis. Autoimmun Rev. 2014;13:435-40.
    2.Lidman K, Biberfeld G, Fagraeus A, Norberg R, Torstensson R, Utter G, Carlsson L, Luca J, et al. Anti-actin specificity of human smooth muscle antibodies in chronic active hepatitis. Clin Exp Immunol. 1976;24:266-72.
    3.Fusconi M, Cassani F, Zauli D, Lenzi M, Ballardini G, Volta U, Bianchi FB. Anti-actin antibodies: a new test for an old problem. J Immunol Methods. 1990;130:1-8.
    4.Chretien-Leprince P, Ballot E, Andre C, Olsson NO, Fabien N, Escande A, Oksman F, Dubuquoi S, et al. Diagnostic value of anti-F-actin antibodies in a French multicenter study. Ann N Y Acad Sci. 2005;1050:266-73.
    5.Carroccio A, Brusca I, Iacono G, Di Prima L, Teresi S, Pirrone G, Florena AM, La Chiusa SM, et al. Anti-actin antibodies in celiac disease: correlation with intestinal mucosa damage and comparison of ELISA with the immunofluorescence assay. Clin Chem. 2005;51:917-20.
    6.Schirru E, Danjou F, Cicotto L, Rossino R, Macis MD, Lampis R, Jores RD, Congia M. Anti-actin IgA antibodies identify celiac disease patients with a Marsh 3 intestinal damage among subjects with moderate anti-TG2 levels. Biomed Res Int. 2013;2013:630463.
    7.Bazzigaluppi E, Parma B, Tronconi GM, Corsin P, Albarello L, Mora S, Barera G. IgA anti-actin antibodies in children with celiac disease: comparison of immunofluorescence with Elisa assay in predicting severe intestinal damage. Ital J Pediatr. 2010;36:25.
    8.Pedreira S, Sugai E, Moreno ML, Vazquez H, Niveloni S, Smecuol E, Mazure R, Kogan Z, et al. Significance of smooth muscle/anti-actin autoantibodies in celiac disease. Acta Gastroenterol Latinoam. 2005;35:83-93.
    9.Clemente MG, Musu MP, Frau F, Brusco G, Sole G, Corazza GR, De Virgiliis S. Immune reaction against the cytoskeleton in coeliac disease. Gut. 2000;47:520-6.
    10.Wunsch E, Milkiewicz M, Norman GL, Laba A, Kruk B, Milkiewicz P. Prognostic significance of anti-gliadin and anti-F-actin immunoglobulin A antibodies in primary sclerosing cholangitis. Pol Arch Intern Med. 2025;135.
    11.von Muhlen CA, Chan EKL, Peebles CL, Imai H, Kiyosawa K, Tan EM. Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases. Clin Exp Immunol. 1995;100:67-74.
    12.Chu CC, Catera R, Hatzi K, Yan XJ, Zhang L, Wang XB, Fales HM, Allen SL, et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 2008;112:5122-9.

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