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AC-30-细颗粒伴有丝分裂板型

同义词 假性-DFS（1）; 细颗粒伴有丝分裂板型 chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
描述 斑点型荧光核型均匀分布于整个间期细胞核，在斑点的大小、亮度和分布上均表现出均一性。在中期极（染色体板）上也可观察到类似的斑点模式。但是，若同时存在核斑点型荧光而且中期极带有均质（透明）纹理，则应归类为混合型核荧光模式（混合型），而非AC-30（2, 3）。 Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.
抗原相关性 modified histone H3, MCA-1

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • AC-30荧光模式常见于无明显自身免疫性疾病的个体。但是，由于该模式可能反映多种抗核抗体的联合反应性，因此偶尔也可见于患有系统性自身免疫性风湿病的患者，特别是在存在多种抗核抗体的情况下（2, 5）。

    ► The AC-28 pattern has low positive predictive value for any disease

    ► Found very infrequently in a routine serology diagnostic setting (120)

    ► Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)

  • 一级信息参考文献
    First level information references

  • 1.Infantino M, Bizzaro N, Grossi V, Manfredi M. The long-awaited 'pseudo-DFS pattern'. Expert Rev Clin Immunol. 2019;15:445.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al. Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop. Autoimmun Rev. 2024;23:103608.

    3.de Melo Cruvinel W, Ferreira GG, de Souza LL, da Costa Veloso Neto W, Gomes CM, Francescantonio PLC, Andrade LEC. The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevance. Clin Chem Lab Med. 2025.

    4.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al. Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation. 2025.

    5.Durmus MA, Komec S. Frequency of the AC-2 pattern's new variant (AC-30) and detection of different immunological relationships. Clin Immunol. 2025;278:110536.

    120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.

    121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.

    122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.

  • 二级信息
    Second level information
  • 无

    ► Autoantibodies to DCA have been described in patients with SLE (18)

    ► Autoantibodies to MCA1 have been described in patients with carcinoma (19)

    ► Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)

  • 二级信息参考文献
    Second level information references
  • 无

    18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.

    19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.

    20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.


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