简体中文

AC-11-光滑核膜型

同义词 核边缘，核膜 Nuclear rim, nuclear envelope/membrane.
描述

细胞核呈均匀荧光，核边缘荧光强度增强；中期、后期染色质无荧光。可观察到相邻细胞接触部位荧光增强。
Homogeneous staining of the nucleus with greater intensity of the outer rim and no staining of the metaphase and anaphase chromatin. Accentuation of fluorescence where adjacent cells touch each other may be observed.
抗原相关性 板层素A，B，C，板层素相关蛋白，或板层素 B 受体（LBR）。 Lamins A,B,C, lamin-associated proteins, or lamin B receptor (LBR).

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations
  • ▶AC‑11 核型在常规自身抗体检测中较少见，可见于自身免疫性血细胞减少症、自身免疫性肝病、带状硬皮病、抗磷脂综合征、系统性自身免疫性风湿疾病，也可出现在无明显自身免疫病的个体；目前关于临床相关性的资料主要基于病例报告和小样本队列研究 [1‑5]。
    ▶识别的抗原包括板层素 (A、B、C) 和 LAP‑2；目前尚无针对这些自身抗体的特异性免疫检测商品化试剂盒 [1‑4]。
    ▶The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenia, autoimmune liver diseases, linear scleroderma, anti-phospholipid syndrome, systemic autoimmune rheumatic diseases, and in individuals with no apparent autoimmune disease; current information on clinical associations is based mainly on case reports and small cohorts [1-5].
    ▶Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available [1-4].
  • 二级信息
    Second level information
  • ▶板层素 B 受体（LBR）抗体可见于原发性胆汁性胆管炎（PBC）[6]。
    ▶LBR antibodies have been described in PBC [6].

  • 参考文献
  • 2026 Topic Review:
    Konstantinov KN, Konstantinov NK, de Melo Cruvinel W, Andrade LEC, Klotz W, Fritzler MJ. Autoantibodies to the nuclear envelope: Functional anatomy of the HEp-2 cell substrate. Autoimmun Rev. 2026:104154.
    1.Coppo P, Clauvel JP, Bengoufa D, Fuentes V, Gouilleux-Gruart V, Courvalin JC, Lassoued K. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol. 2004;77:241-9
    2.Konstantinov K, Foisner R, Byrd D, Liu FT, Tsai WM, Wiik A, Gerace L. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol. 1995;74:89-99
    3.Reeves WH, Chaudhary N, Salerno A, Blobel G. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med. 1987;165:750-62
    4.Senecal JL, Raymond Y. Autoantibodies to DNA, lamins, and pore complex proteins produce distinct peripheral fluorescent antinuclear antibody patterns on the HEp-2 substrate. Arthritis Rheum. 1991;34:249-51
    5.Zhang W, Zhang C, Chen P, Yang C, Gan X, Hussain M, Xun Y, Tian Y, et al. Circulation autoantibody against Lamin A/C in patients with Sjogren's syndrome. Oncotarget. 2016;7:80252-61
    6.Courvalin JC, Lassoued K, Worman HJ, Blobel G. Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. J Exp Med. 1990;172:961-7.

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